Nano-Bee: Thermal Ablation & Extraction

Minimally Invasive Nano therapy for Early-Stage Brain Tumors

Nano-Bee is a radical new platform for treating micro-scale brain tumors designed to liquefy malignant tissue with precision thermal ablation and extract it through a microscopic nasal canal using autonomous nanobots. Our goal is simple but profound: extend patient survival, reduce surgical trauma, and make glioblastoma care more humane, scalable, and cost-effective.

The Problem We’re Solving

Glioblastoma multiforme (GBM) remains one of the deadliest cancers, with survival rates under 15 months and limited options for early-stage intervention. Tumors under 5 mm are often deemed “inoperable” due to their location, size, and the risks of open craniotomy. Even when removed, residual malignant cells frequently seed recurrence.

Current therapies radiation, chemotherapy, and resection are invasive, imprecise, and often devastating. Patients endure neurological complications, long recovery times, and limited hope for remission.

Nano-Bee offers a new path.

Our Solution: Melt, Capture, Extract

Nano-Bee uses swarms of titanium-shell nanobots equipped with MEMS heaters and pore-valves to:

1. Thermally liquefy tumor tissue with sub-0.5 mm precision

2. Load the viscous mass into their hollow cores via heat-actuated pores

3. Self-propel through a 2 mm endonasal micro-canal for non-surgical extraction

This zero-incision, outpatient-ready procedure is designed to complement chemotherapy and extend survival by removing tumor mass early before it spreads or resists treatment.

Technology Stack

• MEMS Thermal Actuators: Pt-resistor heaters with closed-loop PID control

• NiTi Micro-Valves: Fast-response pore arrays for controlled uptake

• Magnetic or Enzyme Propulsion: Navigation through curved nasal canals

• Titanium Drainage Funnel: Orthopedic-grade micro-pipe for safe extraction

• NECTAR Control System: Swarm AI for coordinated targeting and safety

• LIMINA Overlay: Real-time feedback and procedural guidance

Validated in rodent models and synthetic nasal cavities, the system shows promise for safe, precise, and repeatable tumor removal.

Clinical Pathway

• MRI Detection → Stereotactic Injection → Thermal Activation

• Endonasal Canal Placement → Heated-Melt Extraction

• Outpatient Recovery in under 30 minutes

A validated nasal conditioning protocol (saline rinse, NAC gel, lidocaine spray) ensures safe passage and minimal mucosal disruption.

Funding Requirement

We are seeking A$450K in pre-seed investment to build and validate the Nano-Bee prototype, establish in vitro efficacy, and prepare for small-animal trials.

Use of Funds:

• MEMS fabrication and heater calibration

• Titanium micro-canal prototyping

• Synthetic tumor phantom testing

• Rodent glioma model deployment

• Ethics dossier and regulatory mapping (TGA)

This round supports technical buildout, safety validation, and go-to-market readiness for Phase 1 trials.